We introduce a unified framework for evaluating dimensionality reduction techniques in spatial transcriptomics beyond standard PCA approaches. We benchmark six methods PCA, NMF, autoencoder, VAE, and two hybrid embeddings on a cholangiocarcinoma Xenium dataset, systematically varying latent dimensions ($k$=5-40) and clustering resolutions ($ρ$=0.1-1.2). Each configuration is evaluated using complementary metrics including reconstruction error, explained variance, cluster cohesion, and two novel biologically-motivated measures: Cluster Marker Coherence (CMC) and Marker Exclusion Rate (MER). Our results demonstrate distinct performance profiles: PCA provides a fast baseline, NMF maximizes marker enrichment, VAE balances reconstruction and interpretability, while autoencoders occupy a middle ground. We provide systematic hyperparameter selection using Pareto optimal analysis and demonstrate how MER-guided reassignment improves biological fidelity across all methods, with CMC scores improving by up to 12\% on average. This framework enables principled selection of dimensionality reduction methods tailored to specific spatial transcriptomics analyses.

The characterization and analysis of light curves are vital for understanding the physical and rotational properties of artificial space objects such as satellites, rocket stages, and space debris. This paper introduces the Light Curve Dataset Creator (LCDC), a Python-based toolkit designed to facilitate the preprocessing, analysis, and machine learning applications of light curve data. LCDC enables seamless integration with publicly available datasets, such as the newly introduced Mini Mega Tortora (MMT) database. Moreover, it offers data filtering, transformation, as well as feature extraction tooling. To demonstrate the toolkit's capabilities, we created the first standardized dataset for rocket body classification, RoBo6, which was used to train and evaluate several benchmark machine learning models, addressing the lack of reproducibility and comparability in recent studies. Furthermore, the toolkit enables advanced scientific analyses, such as surface characterization of the Atlas 2AS Centaur and the rotational dynamics of the Delta 4 rocket body, by streamlining data preprocessing, feature extraction, and visualization. These use cases highlight LCDC's potential to advance space debris characterization and promote sustainable space exploration. Additionally, they highlight the toolkit's ability to enable AI-focused research within the space debris community.

This paper reports a case study of an application of high-resolution agent-based modeling and simulation to pandemic response planning on a university campus. In the summer of 2020, we were tasked with a COVID-19 pandemic response project to create a detailed behavioral simulation model of the entire campus population at Binghamton University. We conceptualized this problem as an agent migration process on a multilayer transportation network, in which each layer represented a different transportation mode. As no direct data were available about people's behaviors on campus, we collected as much indirect information as possible to inform the agents' behavioral rules. Each agent was assumed to move along the shortest path between two locations within each transportation layer and switch layers at a parking lot or a bus stop, along with several other behavioral assumptions. Using this model, we conducted simulations of the whole campus population behaviors on a typical weekday, involving more than 25,000 agents. We measured the frequency of close social contacts at each spatial location and identified several busy locations and corridors on campus that needed substantial behavioral intervention. Moreover, systematic simulations with varying population density revealed that the effect of population density reduction was nonlinear, and that reducing the population density to 40-45% would be optimal and sufficient to suppress disease spreading on campus. These results were reported to the university administration and utilized in the pandemic response planning, which led to successful outcomes.

Timely, accurate, and reliable information is essential for decision-makers, emergency managers, and infrastructure operators during flood events. This study demonstrates a proposed machine learning model, MaxFloodCast, trained on physics-based hydrodynamic simulations in Harris County, offers efficient and interpretable flood inundation depth predictions. Achieving an average R-squared of 0.949 and a Root Mean Square Error of 0.61 ft on unseen data, it proves reliable in forecasting peak flood inundation depths. Validated against Hurricane Harvey and Storm Imelda, MaxFloodCast shows the potential in supporting near-time floodplain management and emergency operations. The model's interpretability aids decision-makers in offering critical information to inform flood mitigation strategies, to prioritize areas with critical facilities and to examine how rainfall in other watersheds influences flood exposure in one area. The MaxFloodCast model enables accurate and interpretable inundation depth predictions while significantly reducing computational time, thereby supporting emergency response efforts and flood risk management more effectively.

The definition of anomaly detection is the identification of an unexpected event. Real-time detection of extreme events such as wildfires, cyclones, or floods using satellite data has become crucial for disaster management. Although several earth-observing satellites provide information about disasters, satellites in the geostationary orbit provide data at intervals as frequent as every minute, effectively creating a video from space. There are many techniques that have been proposed to identify anomalies in surveillance videos; however, the available datasets do not have dynamic behavior, so we discuss an anomaly framework that can work on very high-frequency datasets to find very fast-moving anomalies. In this work, we present a diffusion model which does not need any motion component to capture the fast-moving anomalies and outperforms the other baseline methods.

Since the late 1950s, when the first artificial satellite was launched, the number of Resident Space Objects has steadily increased. It is estimated that around one million objects larger than one cm are currently orbiting the Earth, with only thirty thousand larger than ten cm being tracked. To avert a chain reaction of collisions, known as Kessler Syndrome, it is essential to accurately track and predict debris and satellites' orbits. Current approximate physics-based methods have errors in the order of kilometers for seven-day predictions, which is insufficient when considering space debris, typically with less than one meter. This failure is usually due to uncertainty around the state of the space object at the beginning of the trajectory, forecasting errors in environmental conditions such as atmospheric drag, and unknown characteristics such as the mass or geometry of the space object. Operators can enhance Orbit Prediction accuracy by deriving unmeasured objects' characteristics and improving non-conservative forces' effects by leveraging data-driven techniques, such as Machine Learning. In this survey, we provide an overview of the work in applying Machine Learning for Orbit Determination, Orbit Prediction, and atmospheric density modeling.

IBM Data and AI general manager Rob Thomas discusses AI being incorporated into the workforce. The labor market may be humming right now, but there may be a dark cloud looming ahead. Over the course of the next decade, up to 800 million jobs globally could disappear due to advances in artificial intelligence and robotics, according to research from the McKinsey Global Institute, a top consulting firm. An estimated one-third of the 2030 workforce in the U.S. may need to learn new skills and find work in new occupations. The changes won't hit the country equally.

The use of robots in the workplace has more than double in just a 12 year period, displacing 50 percent of many human workers across the US, studies have found. A new interactive map provides more detail into this'robot exposure' by highlighting the top 10 metropolitan areas threatened by this machine takeover – California being listed as number one. In addition to areas most at risk, experts found that automation is displacing younger, less-educated and minority workers at the highest rates. The study and map were developed by The Century Foundation, a progressive think tank headquartered in New York City, which looked across more than 250 metropolitan areas to understand this'robot intensity'. Los Angeles, Long Beach and Santa Ana, California were ranked number one, followed by Chicago, Naperville and Joliet in Illinois.

FILE - In this May 13, 2018, file photo, MLB umpire Joe West, right, talks with a player in the ninth inning during a baseball game between the Arizona Diamondbacks and the Washington Nationals in Phoenix. West, who has umpired more than 5,000 big league games, said the 2016 TrackMan computer system test was far from perfect. NEW YORK – Get ready for strikes by robots. Computers will be used for ball/strike calls starting April 25 in the independent Atlantic League, where the distance between home and first will be shortened by 3 inches. The ground between the mound and home plate will lengthen by 2 feet for the second half of the season beginning July 12.

Get ready for strikes by robots. Computers will be used for ball/strike calls starting April 25 in the independent Atlantic League, where the distance between home and first will be shortened by 3 inches. The ground between the mound and home plate will lengthen by 2 feet for the second half of the season beginning July 12. The 60-foot-6-inch distance between the front of the pitching rubber and the back point of home plate has been standard since 1893, but Major League Baseball reached a three-year deal to experiment in the Atlantic League, an eight-team circuit that occasionally produces big leaguers. Infield defensive shifts will be limited.